Mechanism of GSDMD in the Pathogenesis of <i>Pasteurella multocida</i> PmCQ2.

ABSTRACT: Pasteurella multocida serotype A (PmCQ2), a Gram-negative zoonotic pathogen, causes severe respiratory disease in a variety of domestic and wild animals, leading to high morbidity and mortality and substantial agricultural economic losses. Pyroptosis, a gasdermin-mediated programmed cell death mechanism, facilitates pathogen clearance but exacerbates tissue damage through inflammatory cytokine release. While our prior work established PmCQ2-driven NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation, the role of pyroptosis in pulmonary pathology during infection remains unresolved. Here, we demonstrate that PmCQ2 induces macrophage pyroptosis via gasdermin D (GSDMD) cleavage, evidenced by lactate dehydrogenase (LDH) release, membrane pore for

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12894785 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature