Does white matter structure relate to hemispheric language lateralization? A systematic review.

ABSTRACT: The relationship between functional language lateralization and diffusion MRI-based white matter metrics remains a subject of considerable interest and complexity. This systematic review aims to synthesize existing diffusion MRI studies examining white matter correlates of functional language dominance. Twenty-five studies were identified through searches of Web of Science, Scopus and Ovid MEDLINE (search period: inception to 16th May 2023), involving adults with epilepsy, tumours or healthy controls. The results suggest that while the arcuate fasciculus and corpus callosum are commonly associated with language lateralization in clinical populations, the findings in healthy individuals are more variable, often influenced by factors such as handedness. Other white matter tracts, such as unc

SUBMITTER: Andrulyte I 

PROVIDER: S-EPMC12895274 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature