Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

To identify which drugs are effective at preventing delirium after surgery in adults over 60 years of age and estimate the effects on morbidity and mortality.

Design

Systematic review and network meta-analysis.

Data sources

Embase, Medline, and Cochrane Library up to 4 March 2024.

Eligibility criteria

Randomised controlled trials with administration of one or more drugs for the prevention of delirium after surgery requiring general or regional anaesthesia that recruited participants at least 60 years old and used a validated delirium assessment tool to measure the outcome. Surgery under local anaesthesia only, preoperative mechanical ventilation, and studies of interventions to treat delirium were excluded.

Data extraction and synthesis

Assesso

SUBMITTER: Luney M 

PROVIDER: S-EPMC12895303 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature