Spontaneous tauopathy with parkinsonism in an aged cynomolgus macaque.

ABSTRACT:

Introduction

Aged non-human primates have been reported to develop tau pathology; however, most studies lack evidence of any associated neurological symptoms. To determine whether spontaneous tauopathy in cynomolgus macaques manifests with neurological symptoms, we evaluated a symptomatic aged monkey (Monkey T) alongside an asymptomatic control (Monkey A).

Methods

Two male cynomolgus macaques, aged 33-34 years old at the time of necropsy, were examined. They were evaluated using comprehensive behavioral, pathological, and genetic analyses.

Results

Monkey T exhibited progressive neurological symptoms for approximately two years prior to euthanasia, including tremors, nuchal dystonia, and a flexed posture, whereas Monkey A showed no abnormalities. Monkey T demonstrated

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC12895427 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature