Bioinformatics identification and experimental validation of hub genes associated with narcolepsy type 1.

ABSTRACT:

Introduction

Narcolepsy type 1 (NT1) is a chronic neurological disorder with a genetic predisposition, yet its precise molecular pathogenesis remains unclear. Despite increasing recognition of its clinical and genetic basis, the precise molecular mechanisms remain unclear. This study aimed to identify NT1-associated hub genes and investigate their biological functions and interactions through comprehensive bioinformatics analysis, followed by experimental validation.

Methods

NT1-related microarray data (GSE21592) were retrieved from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using integrated analysis with R software and the GEO2R platform. Functional enrichment analyses for Gene Ontology (GO) and Kyoto Encyclopedia of Genes

SUBMITTER: Wang D 

PROVIDER: S-EPMC12895487 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature