Differential Expression and Alternative Splicing Pattern in Female and Male Groups <i>Pelteobagrus ussuriensis</i> with Different Growth Rate.

ABSTRACT: Growth rate is a key trait influencing productivity in aquaculture species, and its regulation often differs between males and females. In this study, Nanopore full-length RNA sequencing was used to investigate sex-specific growth regulation in the liver and brain of Pelteobagrus ussuriensis. Male and female groups each included three fast-growing and three slow-growing individuals. In liver tissue, 332 differentially expressed genes were identified in males and 266 in females. Male-biased genes were mainly involved in lipid and cholesterol metabolism, including the peroxisome proliferator-activated receptor signaling pathway, whereas females showed broader metabolic regulation involving carbohydrate, amino acid, and lipid metabolism, as well as growth-related genes such as IGFBP1,

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12896394 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature