Association of Arterial PaCO₂ with the Survival of Mechanically Ventilated Patients with Acute Respiratory Failure: A Multicenter Retrospective Cohort Study.

ABSTRACT: Background/Objectives: Acute respiratory failure (ARF) is associated with a high mortality. This study aimed to explore the association of arterial partial pressure of carbon dioxide (PaCO₂) in relation to survival outcomes in mechanically ventilated patients with ARF. Methods: This multicenter retrospective cohort study integrated the data from the eICU Collaborative Research Database (eICU-CRD; n = 10,946), the Medical Information Mart for Intensive Care IV (MIMIC-IV; n = 6683), and clinical records from two university-affiliated intensive care units in China (n = 410). The patients were categorized into low, normal, and high PaCO₂ groups using a restricted cubic spline model to explore the relationship between PaCO₂ and mortality. The 28-da

SUBMITTER: Chang L 

PROVIDER: S-EPMC12896418 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature