Optimal α/β Ratio for Biologically Effective Dose-Based Prediction of Radiation-Induced Peritumoral Brain Edema in Meningioma.

ABSTRACT: Background: Peritumoral brain edema (PTBE) is the most frequent complication for intracranial meningiomas following radiotherapy, yet no clinically validated biologically effective dose (BED) threshold capable of reliably predicting PTBE has currently been established. Although conventional radiobiological models typically assume an α/β ratio of 2-4 for benign meningiomas, whether these values accurately reflect the dose-response characteristics underlying radiation-induced PTBE remains unclear. Methods: We analyzed 67 intact meningiomas in the convexity, parasagittal, or falcine regions treated with primary linear accelerator (LINAC)-based radiotherapy. The BED values were recalculated using α/β ratios ranging from 2 to 20, and receiver operating characteristic (ROC) analyse

SUBMITTER: Ko SW 

PROVIDER: S-EPMC12896445 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature