GWAS-Identified SNPs and Candidate Genes Influencing Sex in Loach (<i>Misgurnus anguillicaudatus</i>).

ABSTRACT: Loach (Misgurnus anguillicaudatus) is a small benthic fish favored by consumers in East Asia. Female loaches exhibit greater production value due to their larger size and higher meat yield. Therefore, controlling the sex of loach should be studied to implement an all-female breeding strategy. This study identified sex-related SNP markers and candidate genes in loach through GWAS. Genotyping male and female populations with WGRS revealed 84 SNPs labeled as associated with sex. Distinct SNP peaks appeared on Chr6 and Chr3, with over half of the sex-associated SNPs located on Chr6. Within these sex-associated regions, 15 key candidate genes related to sex and reproduction were identified, including hemgn and foxl2a. Among these genes, pik3cb on Chr3 and hhip

SUBMITTER: Su J 

PROVIDER: S-EPMC12896581 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature