Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer's Disease.

ABSTRACT: Executive dysfunction can precede the accumulation of canonical neuropathological markers and severe dementia in Alzheimer's disease (AD) patients often characterized by memory changes. Deficits in executive function including flexible behavior, i.e., the ability to shift behavior following negative consequences, are often mediated by the prefrontal cortex. However, it is unknown how medial prefrontal cortex activity is altered in behaving Tg-F344-AD rats, which exhibit age-dependent AD pathology and memory deficits. We tested the ability of in 6-7-month-old TgF344-AD rats to learn reward predictive cues and to shift behavior away from cues following outcome devaluation while recording mPFC neurons (wild-type, 10 males and 7 females; TgF344-AD, 8 males and 9 females). Rats were presented w

SUBMITTER: Sloand TJ 

PROVIDER: S-EPMC12896692 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature