Clinical Characteristics and Prognosis of Primary Central Nervous System Lymphoma: A Retrospective Analysis.

ABSTRACT:

Background

Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphoma characterized by a poor prognosis due to high relapse rates and a lack of standardized treatment. This study aimed to evaluate the impact of induction/consolidation therapy on long-term survival and to provide extended follow-up data.

Methods

In this retrospective analysis, 140 immunocompetent patients with diffuse large B-cell PCNSL (DLBCL-PCNSL) treated at two centers between 2014 and 2024 were enrolled. Treatment efficacy was assessed based on baseline characteristics, therapeutic regimens, and treatment response. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method, and prognostic factors were identified using multivariate Cox proport

SUBMITTER: Zhong S 

PROVIDER: S-EPMC12896782 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature