Systemic Inflammatory and Hematological Profiles in Triple-Negative Breast Cancer: A Study from a Senegalese Cohort.

ABSTRACT: Background/Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype associated with a poor prognosis and limited treatment options. Inflammatory and hematological biomarkers have emerged as potential tools for disease characterization, particularly in low-resource settings. Methods: This cross-sectional analytical study was conducted between July 2022 and February 2024 at Dalal Jamm Hospital in Dakar, Senegal, and included 120 women: 40 with TNBC, 40 with hormone-dependent breast cancer (HDBC), and 40 healthy controls. Blood samples were collected at diagnosis before any treatment to measure complete blood counts and C-reactive protein (CRP) levels. Inflammatory ratios-neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-l

SUBMITTER: Barry NOK 

PROVIDER: S-EPMC12897048 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature