Characterization of Clinical Outcomes for Patients with Relapsed High-Risk Neuroblastoma After Autologous Stem Cell Transplant and External Beam Radiotherapy.

ABSTRACT:

Background

Limited data inform the outcomes of patients with high-risk neuroblastoma (HR-NBL) who relapse after high-dose chemotherapy, autologous stem cell transplantation (ASCT), and external beam radiotherapy (EBRT).

Methods

This is a multi-institutional retrospective study of 84 patients with HR-NBL diagnosed between 1997-2021 with a first recurrence after definitive upfront treatment, including ≥1 ASCT and EBRT. Site(s) of first relapse were defined with relation to a patient's primary tumor location. Progression-free survival (PFS) and overall survival (OS) outcomes were analyzed using Kaplan-Meier curves and log-rank tests. Cox proportional hazard models were used for univariate and multivariable analyses.

Results

Twenty-four patients had local recurrences with

SUBMITTER: Lin M 

PROVIDER: S-EPMC12897123 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature