Leukocyte Telomere Length Variants Are Independently Associated with Survival of Patients with Colorectal Cancer.

ABSTRACT: Background and aims: Aberrations in telomere length can have important implications in cancer. Using a cohort of 1007 patients, we investigated whether leukocyte telomere length (LTL) in patients with colorectal cancer (CRC) is associated with survival. We also investigated whether some telomere maintenance genes are associated with survival in these patients. Methods: The Biobank for Gastrointestinal Health Research (BGHR), an ongoing project involving collection of biospecimens at the Mayo Clinic, was utilized to obtain data from patients diagnosed with stage II or III CRC. Blood samples were collected prior to chemotherapy/radiation and DNA was extracted for measuring median LTL. The main outcome measures were overall survival (OS) and disease-free survival (DFS) by diseas

SUBMITTER: Sarkar G 

PROVIDER: S-EPMC12897216 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature