Computed tomography-derived biomechanical simulations as a proof-of-concept tool for evaluating coronary dynamics in anomalous aortic origin of coronary arteries.

ABSTRACT:

Aims

We aim to explore whether biomechanical simulations can identify coronary compression sites and support pre-operative assessment as a proof-of-concept approach in subjects with anomalous aortic origin of a coronary artery.

Methods and results

Patient-specific computer-aided engineering models of the aortic root and coronary arteries were developed from computed tomography scans of subjects with anomalous aortic origin of coronary arteries, retrospectively evaluated to include variants with and without an intramural segment. The fixed and dynamic components of stenosis were assessed by simulating blood pressure from rest to extreme effort and by retrieving the percentage of narrowing of the proximal anomalous lumen with reference to the distal segment. Patients were clas

SUBMITTER: Rosato A 

PROVIDER: S-EPMC12897536 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature