Epileptogenesis and Epilepsy Treatment: Advances in Mechanistic Understanding, Therapeutic Approaches, and Future Perspectives.

ABSTRACT: Epilepsy remains an active and important area of research due to its complex etiology, significant global burden, and variable response to treatment. Current knowledge has provided valuable insights into the underlying molecular mechanisms of the disease and continues to guide the development of novel therapeutic strategies. This review presents a comprehensive overview of the etiologies of epilepsy, as well as traditional and modern medical and surgical treatment approaches, while highlighting future research directions. Peer-reviewed articles retrieved from PubMed and Google Scholar were analyzed and synthesized to produce this review. The etiological complexity of epilepsy arises from genetic, metabolic, structural, and inflammatory mechanisms, which often coexist rather than act indepe

SUBMITTER: Mazhit A 

PROVIDER: S-EPMC12897611 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature