Immunohistochemical Evidence of Telocytic Stroma Associated with Tumor Grade and Acinar Heterogeneity in Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) progression involves dynamic interactions between neoplastic cells and the reactive stroma (RS). Although myofibroblasts are established components of the RS, the role of other stromal populations, such as telocytes, remains poorly understood. This study investigated the presence and distribution of a telocytic stromal phenotype (CD34⁺/Vimentin⁺) in PCa across different histological grades and acinar patterns. We used digital image analysis and standardized immunohistochemistry to assess biopsy samples from 120 patients with confirmed PCa. The telocytic phenotype showed a heterogeneous distribution and was significantly enriched in high-grade tumors and specific acinar architectures, particularly Patterns B and D. In contrast, well-differentiated

SUBMITTER: P Junior E 

PROVIDER: S-EPMC12897662 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature