Interplay Between Fibroblast Growth Factor-19, Beta-Klotho, and Receptors Impacts Cardiovascular Risk in Chronic Kidney Disease.

ABSTRACT: Background: Chronic kidney disease (CKD) markedly increases the risk of cardiovascular events (CVE), yet conventional biomarkers often fail to capture this excess risk. We evaluated whether circulating levels and genetic variability within the FGF19/β-Klotho/FGFR axis contribute to CV risk stratification in CKD. Methods: In 579 CKD patients, plasma FGF19 and β-Klotho concentrations were quantified, and 64 genetic variants across FGF19, KLB, FGFR1, and FGFR4 genes were analyzed. Results: Cluster analysis identified three distinct biomarker profiles, with one cluster-characterized by low/intermediate FGF19 and markedly elevated β-Klotho-showing significantly reduced CV event-free survival. After adjustment for clinical covariates, this cluster was independently associate

SUBMITTER: Gonzalez-Rodriguez L 

PROVIDER: S-EPMC12897728 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature