Isolation and Characterization of 5-(1-Hydroxyethyl)-Dihydro-2-Furanone from <i>Angiopteris evecta</i> with Potent Anti-Inflammatory and Anti-Leukemic Activities.

ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with poor prognosis, frequent relapse, and treatment-related toxicity. The discovery of novel anti-leukemic agents with improved selectivity remains an urgent clinical need. In this study, rhizomes of Angiopteris evecta, a medicinal plant used in Thai traditional medicine, were collected from twelve locations in Thailand and extracted using solvents of increasing polarity. Among thirty-six crude fractional extracts, the ethyl acetate crude fractional extract from source No. 003 (AE EtOAc No. 003) exhibited the strongest cytotoxic activity against KG-1a and EoL-1 leukemic cell lines, with low toxicity toward normal peripheral blood mononuclear cells. Bioactivity-guided fractionation yielded the ternary mixture,

SUBMITTER: Rueankham L 

PROVIDER: S-EPMC12897760 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature