Association Between Heparin Dose, Body Mass Index, and Stroke Risk in Patients Undergoing TAVR.

ABSTRACT: Background: Unfractionated heparin (UFH) is routinely administered during transcatheter aortic valve replacement (TAVR) to prevent thromboembolic complications. However, there are no clear evidence-based guidelines defining optimal heparin dosing or target activated clotting time (ACT) values. This study aimed to evaluate the association between intraprocedural UFH dosing, ACT values, and peri-procedural stroke risk in the overall population of patients undergoing TAVR, with a prespecified stratified analysis according to body mass index (BMI ≥ 30 vs. <30 kg/m²). Methods: This analysis enrolled consecutive individuals with severe aortic stenosis (AS) who were treated with TAVR using either balloon-expandable or self-expanding valves. The primary outcome was the occ

SUBMITTER: Arow Z 

PROVIDER: S-EPMC12897869 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature