Multi-Omics Analysis of a Spontaneous Type 2 Diabetes Model in <i>Myodes rufocanus</i> and Its Underlying Mechanisms.

ABSTRACT: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, progressive β-cell dysfunction, and insulin resistance. While numerous chemically induced and transgenic rodent models exist, spontaneous models recapitulating natural type 2 diabetes mellitus (T2DM) progression remain scarce. Here, we characterize Myodes rufocanus as a novel spontaneous T2DM model through comprehensive assessments of 18-week-old male F6 voles, demonstrating hallmark diabetic features including weight gain, hyperphagia, polydipsia, hyperglycemia, insulin resistance, and dyslipidemia. Pancreatic transcriptomic profiling revealed pronounced COX14 (cytochrome c oxidase assembly factor 14) downregulation, as validated by qPCR and Western blotting in pancreatic tissue and MI

SUBMITTER: Ullah I 

PROVIDER: S-EPMC12898206 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature