Two-Level Meta-Analysis of Genetic and Epigenetic Markers of Asthma in Preschool Children.

ABSTRACT: Background: Genetic variants within the 17q21 locus and epigenetic modifications regulating immune function have been associated with childhood asthma, yet reported effect sizes vary across studies due to methodological heterogeneity and differences in study design. Objectives: To systematically synthesize evidence on genetic and epigenetic markers associated with childhood asthma using a two-level random-effects meta-analysis integrating published meta-analyses and independent cohort studies. Methods: PubMed/MEDLINE and Embase were searched for studies published in English between 2011 and 2024. Eligible studies included pediatric populations with asthma or wheeze phenotypes assessing predefined genetic (ORMDL3, GSDMB) or epigenetic (AHRR, FOXP3, CpG loci) markers and

SUBMITTER: Rsovac S 

PROVIDER: S-EPMC12898218 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature