A Novel Method to Monitor the Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> Biofilms.

ABSTRACT: Biofilms are microbial communities embedded in an extracellular matrix that facilitates their attachment to surfaces. This lifestyle provides advantages to pathogenic bacteria, including increased survival in the presence of antibiotics and an enhanced capacity to develop resistance. Once a biofilm is established, infections get difficult to eradicate and frequently become chronic. There is, therefore, an urgent need to develop novel strategies to counteract biofilm-associated antibiotic resistance. Here, we developed a method to monitor the evolution of antimicrobial resistance, aiming to evaluate novel drugs against bacterial resistance to antibiotics. We validated this methodology using an RNase chimera with antibiofilm activity and a reported ability to hinder colistin resistance in pl

SUBMITTER: Anguita R 

PROVIDER: S-EPMC12898484 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature