The AGE-RAGE Pathway in Endometriosis: A Focused Mechanistic Review and Structured Evidence Map.

ABSTRACT: High Mobility Group Box 1 (HMGB1) and S100 proteins are major ligands of Receptor for Advanced Glycation End-products (RAGE) and have causal roles in endometriosis lesions. Yet the AGE-RAGE pathway that unifies Advanced Glycation End-products (AGEs) with these ligands has not been assessed in endometriosis. In diabetes, atherosclerosis, and chronic kidney disease, AGE-RAGE links insulin resistance and oxidative stress to inflammation, fibrosis, and organ harm. Endometriosis shares key drivers of AGE accumulation, including insulin resistance, oxidative stress, and chronic inflammation. Endometriosis is also linked to higher vascular risk and arterial stiffness. We asked whether AGE-RAGE could bridge metabolic stress to pelvic lesions and systemic risk. We did a focused review of mechanisms

SUBMITTER: Martinelli C 

PROVIDER: S-EPMC12898717 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature