Determinants and Phenotypes of Poorly Controlled COPD Using the RADAR Score: A Cohort in Real-World Primary Care.

ABSTRACT: Background: Poor clinical control in Chronic Obstructive Pulmonary Disease (COPD) is prevalent, yet the interplay of disease severity, modifiable factors, and clinician perception remains poorly understood. This study aimed to determine the frequency of poor control, identify its independent determinants, and characterize the heterogeneity of the poorly controlled population receiving maintenance inhaled therapy with various devices in primary care. Methods: In a multicenter, cross-sectional analysis of 988 patients from the Study SIMPLIFY, clinical control of COPD was classified using the objective RADAR score. We used multivariable logistic regression and Machine Learning (Random Forest with SHAP analysis) to identify determinants of poor control (RADAR ≥ 4) and k-medoids c

SUBMITTER: Calle Rubio M 

PROVIDER: S-EPMC12898748 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature