Immunomodulatory Effects of <i>Phallus indusiatus</i> Extract on Cytokine Responses in PBMCs: Implications for Feline Infectious Peritonitis.

ABSTRACT: Feline infectious peritonitis (FIP) is a fatal disease driven by feline coronavirus induced immune dysregulation and excessive inflammatory cytokine production. Immunomodulatory agents capable of rebalancing this response are therefore of increasing interest. Phallus indusiatus (P. indusiatus), an edible mushroom containing diverse bioactive compounds, has previously demonstrated antiviral and anti-inflammatory potential. This study investigated the immunomodulatory effects of P. indusiatus extract on peripheral blood mononuclear cells (PBMCs) from healthy cats and FIP cats and characterized its chemical constituents using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). PBMCs were isolated from whole blood and FIP fluid. Cytotoxicity screening i

SUBMITTER: Hlaoperm C 

PROVIDER: S-EPMC12898788 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature