A Cu(II)-Based Fluorescent Probe for Carbon Monoxide, Nap-BC-Cu(II), Does Not Selectively Detect Carbon Monoxide.

ABSTRACT: Reports of carbon monoxide (CO) pharmacology have spurred intense interest in developing its fluorescent probes with much success. However, one unfortunate event in this area is the wide-spread use of chemically reactive metal/BH₃-CO complexes as "CO-releasing molecules" or CORMs that do not produce CO or produce CO in an idiosyncratic fashion. Consequently, a large number of reported fluorescent "CO probes" only respond to the CORM used, but not to CO. Though most of these issues have been clarified in the literature, there is a surprising recent publication on a Cu(II)-based fluorescent "CO probe," Nap-BC-Cu(II), relying on undefined chemical principles. We reassessed the ability for Nap-BC-Cu(II) to detect CO and found no evidence for Nap-BC-Cu(II) to selectively detect CO at

SUBMITTER: Liu D 

PROVIDER: S-EPMC12898799 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature