Aerobic exercise inhibits oxidative stress and improves diabetic cardiomyopathy in rats by activating the PROC/PAR1/Nrf2/HO-1 signaling pathway.

ABSTRACT: Diabetic cardiomyopathy (DCM) is a serious complication of end-stage diabetes that manifests as cardiac hypertrophy and heart failure. The present study performed a bioinformatics analysis to predict possible targets for aerobic exercise to improve DCM, and animal experiments were conducted to detect the relevant mechanisms. Oxidative stress (OS)-DCM-trained differentially expressed genes (DEGs) were retrieved from the GeneCards database and a Gene Expression Omnibus microarray dataset. Subsequently, a protein-protein interaction network was constructed to screen the hub genes of the OS-DCM-trained DEGs. In addition, a model of type 2 diabetes was established using streptozotocin and a high-fat diet. Rats were divided into the control, DCM and DCM plus exercise (DCME) groups. The DCME grou

SUBMITTER: Xie S 

PROVIDER: S-EPMC12898814 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature