<i>STAT3^R152W</i> Mutation Model Reveals Temporal Changes in Hematopoietic Populations.

ABSTRACT: Inconsistent presentation of STAT3 variants in clinical settings makes them challenging to use in diagnostics and the prevention of unfavorable outcomes. Patients harboring the STAT3^R152W variant display a range of autoimmune disorders, including type 1 diabetes, hemolytic anemia, and thrombocytopenia. Because of a complex interplay of genetic and environmental cofactors, it is difficult to discern the direct role STAT3 plays in the development of those conditions. Here, we report a mouse model of the STAT3^R152W variant and describe its hematopoietic populations throughout adulthood. We observed profound changes in both innate and adaptive immunity, including increased splenic Th17 component consistent with a gain-of-function mutation, as describe

SUBMITTER: Jankowski J 

PROVIDER: S-EPMC12898827 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature