Bioactive Potential and COX-2 Interaction of <i>Ajuga iva</i> (L.) Schreb. Hydroalcoholic Extract: Evidence from Experimental and Computational Studies.

ABSTRACT: Ajuga iva (L.) Schreb. is traditionally used in North African ethnomedicine for the management of inflammation, pain, and fever. The present study aimed to characterize the phytochemical profile of the hydroalcoholic extract of its aerial parts and to evaluate its anti-inflammatory, analgesic, and antipyretic activities using established in vivo models. Preliminary phytochemical screening confirmed the presence of major classes of secondary metabolites, including polyphenols, flavonoids, tannins, and glycosidic compounds. Quantitative assays revealed appreciable levels of total phenolics (26.3 ± 1.2 mg GAE/g extract) and flavonoids (13.5 ± 0.9 mg QE/g extract). In vivo pharmacological evaluation demonstrated significant biological activities, with the highest tested dose (400 mg/kg)

SUBMITTER: Boutora Y 

PROVIDER: S-EPMC12898832 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature