3-Hydroxypropionic Acid Enhances Hair Growth-Related Signaling in Human Follicle Dermal Papilla Cells via Activation of the Wnt/β-Catenin Pathway.

ABSTRACT: Hair loss is a common condition that affects a large number of people worldwide, impacting both men and women. Its development is closely linked to the function of hair follicle dermal papilla cells (HFDPCs), which play a pivotal role in maintaining hair growth and follicle integrity. However, these cells are particularly vulnerable to oxidative stress generated under psychological or environmental stressful conditions. Preserving the mitochondrial function and biological activity of HFDPCs is critical for preventing stress-related hair loss. This study investigated the protective and hair growth-promoting effects of 3-hydroxypropionic acid (3-HP), a naturally occurring organic acid with antioxidant potential, on HFDPCs exposed to H₂O₂-induced oxidative stress conditi

SUBMITTER: Jeon CY 

PROVIDER: S-EPMC12898851 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature