Evaluation of Risk Factors for Failed Seroconversion in the Management of Potential Lyssavirus Exposures.

ABSTRACT:

Background

Although failure of rabies postexposure prophylaxis is rare, several factors, including improper vaccine or rabies immunoglobulin administration, may increase the risk. Where there is the potential for postexposure prophylaxis failure, public health units may recommend serology to confirm a therapeutic immune response. This study evaluates which factors increase the risk of failed seroconversion in cases where serology was indicated after rabies postexposure prophylaxis.

Methods

Potential lyssavirus exposure notifications where serology was collected were identified from 5 Southeast Queensland public health units from June 2015 to December 2022. Data on the indication and outcome of serology were extracted from public health case notes. Descriptive analysis was pe

SUBMITTER: Harris J 

PROVIDER: S-EPMC12898917 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature