Phenotype-Specific Mitochondrial Responses to Mediterranean Diet and Exercise in Elderly Obesity.

ABSTRACT: Background/Objectives: While excessive body fat is commonly linked to metabolic disorders (metabolically unhealthy obesity, MUO), a subset of individuals remain metabolic healthy despite obesity (metabolically healthy obesity, MHO). This work aims to determine how these phenotypes influence responses to lifestyle modification (LSM) in older adults. Methods: A 12-month lifestyle modification (LSM) intervention based on the Mediterranean Diet (MedDiet) and regular physical activity (PA) was conducted in 43 older adults (70% women) classified according to World Health Organization (WHO) criteria as MHO (22 subjects) or MUO (21 subjects). Clinical, dietary, and PA parameters were assessed at baseline and follow-up. Peripheral blood mononuclear cells were analyzed for mitochondria

SUBMITTER: Carrillo-Fernandez P 

PROVIDER: S-EPMC12899043 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature