<i>Ent</i>-Clerodane Diterpenoid Inhibitors of Glucose-6-phosphatase from <i>Croton guatemalensis</i> Lotsy.

ABSTRACT: The Croton genus includes a diverse group of plants with remarkable potential in natural products research, particularly due to their bioactive compounds with hypoglycemic and phytochemical significance. This study examines Croton guatemalensis Lotsy, focusing on its chemical composition and its biological efficacy as a glucose-6-phosphatase inhibitor. Phytochemical analysis led to the isolation and structural elucidation of eleven compounds (1-11), including three new ent-clerodane diterpenes, designated crotoguatenoic acids C (9), D (10), and E (11). The absolute configurations of compounds 9-11 were determined by electronic circular dichroism (ECD) as (5R,8R,9R,10S)-configured ent-clerodane

SUBMITTER: Escandon-Rivera SM 

PROVIDER: S-EPMC12899306 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature