Chitosan/Carboxymethyl Cellulose Nanocomposites Prepared via Electrolyte Gelation-Spray Drying for Controlled Ampicillin Delivery and Enhanced Antibacterial Activity.

ABSTRACT: This study reports the fabrication of chitosan/carboxymethyl cellulose (C/M) nanocomposites by electrolyte gelation-spray drying and the evaluation of their antibacterial performance as carriers for the antibiotic ampicillin. Chitosan (C), a cationic biopolymer derived from chitin, was combined with the anionic polysaccharide carboxymethyl cellulose (M) at different mass ratios to form stable nanocomposites via electrostatic interactions and then collected in a spray dryer. The resulting particles exhibited mean diameters ranging from 800 to 1500 nm and zeta potentials varying from +90 to -40 mV, depending on the C/M ratio. The optimal formulation (C/M = 2:1 ratio) achieved a high recovery yield (71.1%), lower PDI (0.52), and ampicillin encapsulation efficiency EE (82.4%). Fourier transfor

SUBMITTER: Nguyen AD 

PROVIDER: S-EPMC12899446 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature