From Elderflower to Bioactive Extracts: Phytochemical Characterization and Anti-Inflammatory Activity.

ABSTRACT: This study provides a phytochemical characterization of Sambucus nigra L. (elderflower) and correlates its chemical profile with anti-inflammatory bioactivity, establishing an optimized extraction methodology. A comparative analysis of ultrasound-assisted extraction (UAE), accelerated solvent extraction (ASE), and shaking maceration was conducted using solvents of varying polarity (ethanol, ethanol-water mixture (1:1, v/v), and water). High-resolution fingerprinting via HPLC-ESI-QTOF-MS/MS confirmed a rich polyphenolic profile, dominated by flavonoids such as rutin, naringenin, and phenolic acids, notably chlorogenic acid. Quantitative analysis revealed that UAE with ethanol-water mixture (1:1, v/v) for 20 min yielded the highest recovery of rutin (4.87%)

SUBMITTER: Koval M 

PROVIDER: S-EPMC12899531 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature