The Synthesis, Metal Exchange, and Hyaluronate Functionalization of a Cationic Gallium-Based Thiosemicarbazone Anticancer Drug.
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ABSTRACT: We herein demonstrate that the thiosemicarbazone (TSC) ligand N'-(di(pyridin-2-yl)methylene)-4-(thiazol-2-yl)piperazine-1-carbothiohydrazide (HL) can coordinate with Ga3+ to give cationic complex [Ga(L)2]NO3 featuring an octahedral Ga(III) center. [Ga(L)2]NO3 undergoes metathesis with both Fe2+ and Fe3+, resulting in the formation of respective Fe2+- and Fe3+ complexes. [Ga(L)2]NO3 is also susceptible to anion exchange with sodium hyaluronate (NaA) to produce the nanoformulation [Ga(L)2]A with boosted aqueous solubility and cell targeting. [Ga(L)2]A demonstrated remarkable in vitro cytotoxicity against NCI-H
SUBMITTER: Ning Y
PROVIDER: S-EPMC12899563 | biostudies-literature | 2026 Feb
REPOSITORIES: biostudies-literature
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