Genetic Variation in Response to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND): A Randomized Controlled Trial.

ABSTRACT: Background: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study was a 3-year randomized controlled trial to test the effects of the MIND diet on cognitive decline in individuals at risk for Alzheimer's dementia (AD). Here we examine whether genetic differences in (a) AD predisposition and (b) nutrient metabolism modify the effect of MIND on cognitive change. Methods: This secondary analysis included 494 trial participants of genetically inferred European ancestry with genetic data. Genetic scores (GS) were derived from prior genome-wide studies of AD and nutrient biomarkers. Linear regression and linear mixed models were used to examine the main effects of GS and interactions with diet assignment on cognition. An exploratory genome-wide interaction an

SUBMITTER: Cornelis MC 

PROVIDER: S-EPMC12899571 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature