Hepatic UGT2B-Mediated Testosterone Clearance Promotes Lipid Accumulation in High-Fat-Diet-Induced MASLD.

ABSTRACT: Background and Objective: Male individuals diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD) frequently present with decreased blood testosterone concentrations concomitant with increased levels of hepatic cholesterol, the fundamental substrate for testosterone synthesis; however, the mechanistic relationship between these phenomena remains inadequately elucidated. This study aimed to examine the involvement of hepatic cholesterol biosynthesis and testosterone metabolism in the pathogenesis of MASLD. Methods: An MASLD model was established in male C57BL/6J mice subjected to a high-fat diet (HFD). Comprehensive analyses, including hepatic transcriptomics, metabolomics, enzyme-linked immunosorbent assay, Western blotting, and quantitative polymeras

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12899675 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature