Anti-Inflammatory Effects of Bisacurone Isolated from <i>Curcuma longa</i> (Ryudai Gold): An In Vivo and In Silico Study.

ABSTRACT: Bisacurone is a sesquiterpenoid constituent of Curcuma longa that has received considerably less attention than curcuminoids despite emerging evidence of its biological activity. In this study, the anti-inflammatory potential of bisacurone isolated from the Ryudai gold variety of Curcuma longa was evaluated using an integrated in vivo and in silico approach. Acute inflammation was assessed in rats using a carrageenan-induced paw edema model, supported by histopathological examination of paw tissues. Bisacurone significantly reduced paw edema during the peak inflammatory phase and markedly attenuated dermal thickening and inflammatory cell infiltration, indicating effective suppression of acute inflammatory responses. The effects of bisacurone were comparable to that of indome

SUBMITTER: Anjum M 

PROVIDER: S-EPMC12899999 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature