The Role of Selenium During Gestation in the Development of Fetal Congenital Anomalies: A Systematic Review.

ABSTRACT: Background/Objectives: During intrauterine development, cell proliferation, differentiation, and apoptosis are strictly regulated for organogenesis to be ensured; disruption of these processes, e.g., by oxidative stress, may lead to congenital anomalies. This systematic review aimed to examine the role of selenium (Se), an important antioxidant, during gestation in the development of congenital anomalies. Methods: To identify relevant original research studies in English, PubMed, Embase, and Cochrane Library were systematically searched up to December 2025. A qualitative synthesis, quality appraisal, and assessment of predefined sources of bias and heterogeneity were performed. Results: 2743 titles and abstracts were screened, 473 full texts assessed, and 31 papers inc

SUBMITTER: Stachika N 

PROVIDER: S-EPMC12900013 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature