Multiplexed luminal tissue constructs with reconfigurable barriers for dynamic modeling of multi-tissue interactions.

ABSTRACT: Cell-lined luminal structures are crucial for nutrient transport, tissue barriers, and paracrine interactions. Modeling these structures is essential for developing accurate in vitro models, but conventional systems struggle with their geometrical complexity. While recent microengineering and self-assembly platforms have shown promise, they face limitations in throughput, equipment compatibility, and operational complexity. To address these challenges, we have developed an array of three-dimensional tissue constructs with luminal structures that overcome current limitations. Our platform employs a sacrificial micromolding technique to generate arrays of luminal structures within extracellular matrix hydrogels in a single process, improving throughput. We also incorporate a reconfigu

SUBMITTER: Humayun M 

PROVIDER: S-EPMC12900169 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature