Prenatal exposure to per- and polyfluoroalkyl substances and risk of autism spectrum disorder in the California Central Valley, 2004-2010.

ABSTRACT:

Background

There is mixed evidence regarding the association between per- and polyfluoroalkyl substances (PFAS) and autism spectrum disorder (ASD).

Methods

We matched 294 ASD cases to 286 controls by sex, birth year, and exposure to selected pesticides and air pollution. All participants were born in the California Central Valley from 2004 to 2010. Using high-resolution metabolomic profiling, three PFAS were measured in >60% of maternal serum samples: perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid, and perfluorooctane sulfonate (PFOS). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using logistic regression to examine relationships between PFAS and ASD. Nonlinear associations were examined using restricted cubic spline regression,

SUBMITTER: Osborne K 

PROVIDER: S-EPMC12900219 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature