<i>Lactobacillus paracasei</i> WIS43 alleviates DSS-induced colitis by modulating gut microbiota and suppressing inflammation.

ABSTRACT:

Introduction

Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon with rising incidence and limited therapeutic options. Probiotics are increasingly recognized as potential interventions, but strain-specific differences remain insufficiently defined.

Methods

We conducted a meta-analysis of publicly available microbiome datasets to characterize disease-associated dysbiosis, focusing on the genus Lactobacillus. We then evaluated Lactobacillus paracasei WIS43, a novel strain isolated from the breast milk of a healthy volunteer, in a dextran sulfate sodium (DSS)-induced murine colitis model, using mesalazine and the commercial strain Lactobacillus paracasei LPC-37 as comparators. Disease severity, histopathology, inflammatory cytokines, an

SUBMITTER: Fu Y 

PROVIDER: S-EPMC12900382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature