Longitudinal trends in community-onset bacteraemia caused by ceftriaxone non-susceptible <i>Escherichia coli, Proteus mirabilis, Klebsiella oxytoca</i>, and <i>Klebsiella pneumoniae</i> (2016-2024).

ABSTRACT:

Background

The increasing prevalence of ESBL-producing Enterobacterales complicates treatment and worsens outcomes. However, contemporary data describing the prevalence and temporal trends in established risk factors for community-onset ceftriaxone non-susceptible (CRO-NS) bacteraemia remain limited.

Methods

This retrospective cohort study included adults with community-onset bacteraemia due to Escherichia coli, , Klebsiella pneumoniae, Klebsiella oxytoca, or Proteus mirabilis, evaluated at Phoebe Putney Health System (Albany, GA) between January 2016 and November 2024. Community-onset was defined by the first positive blood culture collected in the ER or ≤48 h of presentation. CRO susceptibility was determined by institutional antimicrobial susce

SUBMITTER: Patel R 

PROVIDER: S-EPMC12900576 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature