Investigation of Carbonic Anhydrase Inhibition, Antioxidant Properties, and Selective Anticancer Activity of Methyl-Substituted Halogenated and Methoxy Conduritols.

ABSTRACT:

Introduction

This study aimed to investigate the anticancer, potential antiepileptic agents, and antioxidant potentials of 10 methyl-substituted halogenated and methoxy conduritols, which had been previously synthesized and characterized. The presence of active functional groups within their structures suggested their potential as bioactive molecules. Both in vitro and in silico approaches were employed to assess their biological activities and therapeutic relevance.

Methods

Anticancer activity was tested using the MCF-7 breast cancer cell line and the L929 fibroblast cell line, with IC₅₀ values calculated to evaluate cytotoxicity. Antioxidant activity was determined using DPPH, FRAP, and TAS assays. The effects of methyl-substituted mono- and dimethoxy halogenate

SUBMITTER: Bostancı HE 

PROVIDER: S-EPMC12900579 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature