Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients.

ABSTRACT:

Background

Breast cancer chemotherapy increases cardiovascular (CV) risk, particularly in postmenopausal women. Although vascular damage, endothelial dysfunction, and oxidative stress are implicated, the role of menopausal status in vascular mechanisms of increased CV risk remains unknown. Accordingly, we investigated whether estrogens protect premenopausal women from neoadjuvant chemotherapy (TAC protocol)-induced endothelial dysfunction, focusing on the vascular effects of docetaxel. This is the first study to assess how menopausal status affects vascular responses to chemotherapy.

Objectives

The main objective was to elucidate the pathophysiologic mechanisms by which TAC precipitates vascular dysfunction, with an emphasis on the influence of menopausal status.

Methods<

SUBMITTER: Szczepaniak P 

PROVIDER: S-EPMC12900610 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature