Meningeal lymphatic vessel dysfunction exacerbates brain injury in CVST mice via endoplasmic reticulum and oxidative stress pathways.

ABSTRACT:

Objective

Meningeal lymphatic vessels (mLVs) play a significant role in neurological homeostasis and disease. However, their contribution to brain injury following cerebral venous sinus thrombosis (CVST) remains unknown. This study investigated whether mLV dysfunction influences the pathological progression of CVST by regulating the endoplasmic reticulum (ER) and oxidative stress(OS)pathways.

Method

A total of 65 male C57BL/6J mice were randomly assigned to four groups: sham-operated, CVST; CVST combined with cervical lymph node ligation (CVST + Ligation); and 4-phenylbutyric acid (4-PBA) intervention. The CVST model was established by inducing thrombosis in the superior sagittal sinus. All sample collection and experimental assays were performed at 2 days post-modeling. Neu

SUBMITTER: Ying J 

PROVIDER: S-EPMC12900663 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature