Admission HDL-C and recurrence risk of hypertriglyceridemia-induced acute pancreatitis: a multicenter cohort study.

ABSTRACT:

Background

Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) carries a high risk of post-discharge recurrence. Whether admission high-density lipoprotein cholesterol (HDL-C) independently predicts recurrence and how its effect varies over time remain unclear.

Methods

A multicenter retrospective study was conducted, including consecutive HTG-AP inpatients from three hospitals from January 2020 to March 2025. The primary endpoint was overall post-discharge recurrence; while the secondary endpoints included recurrence within 6 and 12 months. HDL-C, analyzed both as a continuous variable and by tertiles, was evaluated using Cox models with progressive adjustment. Dose-response was examined by restricted cubic splines (RCS). Time-varying effects were assessed with landmark

SUBMITTER: Liu J 

PROVIDER: S-EPMC12900692 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature