Dose-response meta-analysis of plasma TMAO and stroke: validated linear risk threshold at 3.0 μmol/L.

ABSTRACT:

Background

Stroke, especially the ischemic type, remains a leading global cause of death and disability, with modifiable risk factors offering prevention opportunities. Trimethylamine N-oxide (TMAO), a gut-derived metabolite, promotes vascular damage and is linked to stroke risk. Although prior studies have explored dose-response relationships, clinically actionable thresholds remain undefined, limiting translational applications. This study aims to advance the field by quantifying a continuous dose-response relationship and determining a specific risk threshold, which is currently lacking, to inform preventive strategies.

Methods

This PRISMA-compliant meta-analysis included 11 observational studies (n = 7,556) and encompassed two components: an overall meta-analysis

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12900722 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature